Nenasheva Valentina Valer’evna | Institute of Molecular Genetics

Nenasheva Valentina Valer’evna

Academic degree:
Doctor of Philosophy (Biology)

Academic title:
without academic rank


Division of IMG:
Laboratory of genome replication and repair

Position:
Senior Researcher


Telephone:
+7-499-196-18-62

Е-mail:
nenasheva@img.ras.ru

Resume (CV):
Microsoft Office document icon nenashevavalentina.doc



Main research interests

The study of the molecular mechanisms of lymphomagenesis in humans and monkeys. The found genes involved in virus-associated lymphomagenesis in humans and monkeys.
Properties of trim14 TRIM14 gene, its participation in the virus-associated lymphomagenesis and in the immune defense of human cells from viral and bacterial infections. It has been shown that the increase in trim14 TRIM14 gene expression suppressed alphavirus Sindbis replication, and there were changes in the transcription of a large number of genes of the immune system (Nenasheva et al. Immunol Res. 2015 Jul;62(3):255-62)


Publications

  1. Nikolaev AI, Henning H, Mukhoian IA, Nenasheva VV, Kalmyrzaev BB, Dubovaia VI, Hunsmann G, Bodemer V, Tarantul VZ. Analysis of lymphoma-specific transcripts in B-cell non-Hodgkin's lymphoma patients, infected by the human immunodeficiency virus type 1. Mol Biol (Mosk). 1999, 33(2):252-60.
  2. Tarantul V., Nikolaev A., Hannig H., Kalmyrzaev B., Muchoyan I., Maximov V., Nenasheva V., DubovayaV., HunsmannG., Bodemer W., Detection of abundantly transcribed genes and gene translocation in human immunodeficiency virus associated non-Hodgkin's lymphoma, Neoplasia, 2001, v. 3, N. 2, p. 132-142.
  3. Nenasheva VV, Maksimov VV, Nikolaev AI, Tarantul VZ. Comparative analysis of the level of gene transcription in two types of HIV-associated lymphoma. Mol Gen Mikrobiol Virusol. 2001;(4):27-31.
  4. Aniskina IuV, Gornostaeva SI, Andreeva LE, Nenasheva VV, Tarantul VZ, Nikolaev AI. Viral promoter-enhancer element inhibits replication of autonomously replicating plasmid in mammalian cells. Mol Biol (Mosk). 2003, 37(5):876-84.
  5. Nenasheva VV, Nikolaev AI, Dubovaia VI, Inozemtseva LS, Manuilova ES, Martynenko AV, Tarantul VZ. Analysis of expression of a series of lymphoma-specific genes in human fibroblasts immortalized by SV40 virus. Mol Biol (Mosk). 2004, 38(2):265-75.
  6. Nenasheva VV, Nikolaev AI, Martynenko AV, Kaplanskaya IB, Bodemer W, Hunsmann G, Tarantul VZ. Differential gene expression in HIV/SIV-associated and spontaneous lymphomas. Int J Med Sci. 2005;2(4):122-8.
  7. Kovaleva G. V., Nenasheva V. V., Sedova E. S., Tarantul V. Z. The enhanced expression of pub gene (trim-14) is associated both with HIV infection and with the late studies of Influenza virus infection. The Materials of VII International scientific practice conference «ACHIEVEMENT OF HIGH SCHOOL - 2011» 17 – 25 November 2011, Biology. Ecology. Geography and geology. 2011. V. 25. P. 8-12.
  8. Makarova IV, Kazakov AA, Makarova AV, Khaidarova NV, Kozikova LV, Nenasheva VV, Gening LV, Tarantul VZ, Andreeva LE. Transient expression and activity of human DNA polymerase iota in loach embryos. Biotechnol Lett. 2012, 34(2):205-12.
  9. Milon BC, Cheng H, Tselebrovsky MV, Lavrov SA, Nenasheva VV, Mikhaleva EA, Shevelyov YY, Nurminsky DI. Role of histone deacetylases in gene regulation at nuclear lamina. PLoS One. 2012;7(11):e49692. doi: 10.1371/journal.pone.0049692.
  10. Nenasheva VV, Kovaleva GV, Khaidarova NV, Novosadova EV, Manuilova ES, Antonov SA, Tarantul VZ. Trim14 overexpression causes the same transcriptional changes in mouse embryonic stem cells and human HEK293 cells. In Vitro Cell Dev Biol Anim. 2014, 50(2):121-8. doi: 10.1007/s11626-013-9683-4.
  11. Nenasheva VV, Kovaleva GV, Uryvaev LV, Ionova KS, Dedova AV, Vorkunova GK, Chernyshenko SV, Khaidarova NV, Tarantul VZ. Enhanced expression of trim14 gene suppressed Sindbis virus reproduction and modulated the transcription of a large number of genes of innate immunity. Immunol Res. 2015, 62(3):255-62. doi: 10.1007/s12026-015-8653-1.
  12. Gening L.V., Lakhin A.V., Makarova I.V., Nenasheva V.V., Andreeva L.E., Tarantul V.Z. Alterations in synthesis and repair of dna during the development of loach Misgurnus fossilis. J. Develop. Biol., 2016, 4, doi:10.3390/jdb4010006.
  13. Nenasheva V.V., Novosadova E.V., Makarova I.V., Lebedeva O.S., M. A. Grefenshtein, E. L. Arsenyeva, S. A. Antonov, Grivennikov I.A., Tarantul V.Z. The Transcriptional Changes of trim Genes Associated with Parkinson’s Disease on a Model of Human Induced Pluripotent Stem Cells. Molecular Neurobiology, 2017, 54(9), 7204-7211. DOI: 10.1007/s12035-016-0230-7